Solid Phase Peptide Synthesis Approach to long and Cyclic Peptide Synthesis
For example, dipeptide repeats have been implicated in a number of disorders. We have successfully prepared many long to very long direpeats, including proline-containing poly(Pro-lys)20 that have been associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
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